SynVivo Chips

SynVivo is a microchip platform that provides a physiologically realistic microfluidic environment that allows the real-time study of cellular behavior and drug delivery. SynVivo recreates the complex in vivo vasculature including scale, morphology, fluidics and cellular interactions in an in vitro environment enabling basic and applied life sciences research.

SynVivo Chips are available for purchase to use in research studies. Please visit our SynVivo microsite for more information and to request a quote. Contact This email address is being protected from spambots. You need JavaScript enabled to view it. to discuss your SynVivo application needs.

Applications include:

  • Basic research on:
    • Cellular behavior and microcirculatory dysfunction
    • Drug particle adhesion and uptake mechanisms
  • Drug delivery particles and optimization
  • Drug discovery in:
    • Inflammation (Host immune response)
    • Cancer (Tumor microenvironment)
    • Thrombosis (Blood cell interactions)
    • Infectious disease (Host pathogen interactions)
  • Drug candidate efficacy and toxicology evaluations

Publications:

  • Microfluidic devices for modeling cell-cell and particle-cell interactions in the microvasculature. Prabhakarpandian B, Shen MC, Pant K, Kiani MF. Microvasc Res. 2011 Nov;82(3):210-20.
  • Bifurcations: focal points of particle adhesion in microvascular networks. Prabhakarpandian B, Wang Y, Rea-Ramsey A, Sundaram S, Kiani MF, Pant K. Microcirculation. 2011 Jul;18(5):380-9
  • Flow and adhesion of drug carriers in blood vessels depend on their shape: a study using model synthetic microvascular networks. Doshi N, Prabhakarpandian B, Rea-Ramsey A, Pant K, Sundaram S, Mitragotri S. J Control Release. 2010 Sep 1;146(2):196-200 
  • Preferential adhesion of leukocytes near bifurcations is endothelium independent. Tousi N, Wang B, Pant K, Kiani MF, Prabhakarpandian B. Microvasc Res. 2010 Dec;80(3):384-8.
  • Quantifying Gene Delivery Using Synthetic Microvascular Networks. Prabhakarpandian B, Fewell JG, Rea-Ramsey A, Pant K, Matar M, Anwer K. 12th Annual Meeting of the American Society of Gene Therapy, May 27-30, 2009, San Diego, CA
  • A physiologically realistic in vitro model of microvascular networks. Rosano JM, Tousi N, Scott RC, Krynska B, Rizzo V, Prabhakarpandian B, Pant K, Sundaram S, Kiani MF. Biomed Microdevices. 2009 May 19.
  • Synthetic microvascular networks for quantitative analysis of particle adhesion. Prabhakarpandian B, Pant K, Scott RC, Patillo CB, Irimia D, Kiani MF, Sundaram S. Biomed Microdevices. 2008 Aug;10 (4):585-95

Patents Awarded/Pending:

  • "Synthetic Microvascular Networks "; U.S. Patent #7,725,267 (open for license)
  • "Synthetic Microfluidic Microvascular Networks"; U.S. Patent #8,175,814 (open for license)
  • "Idealized Synthetic Microvasculature Chip (SMN)"; Patent Pending (open for license)
  • "Synthetic Microvascular Networks - Blood Brain Barrier"; Patent Pending (open for license)
  • "SMN for Leukocyte Adhesion"; Patent Pending (open for license)
  • "SMN for Tumor Drug Delivery"; Patent Pending (open for license)