Synthetic Microvascular Networks (SMN)
SMN is a microchip platform that provides a physiologically realistic microfluidic environment that allows the real-time study of cellular behavior and drug delivery. SMN recreates the complex in vivo vasculature including scale, morphology, fluidics and cellular interactions in an in vitro environment enabling basic and applied life sciences research.
Applications include:
- Basic research on:
- Cellular behavior and microcirculatory dysfunction
- Drug particle adhesion and uptake mechanisms
- Drug delivery particles and optimization
- Drug discovery in:
- Inflammation (Leukocyte adhesion cascade)
- Cancer (Tumor cell dynamics)
- Thrombosis (Blood cell adhesion)
- Infectious disease (Microbial adhesion)
- Drug candidate efficacy and toxicology evaluations
